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What is plaque

Plaque psoriasis is caused by an overactive immune system and is the most common form of psoriasis. The overactive immune system causes skin cells to rapidly build up, forming psoriasis plaques. Why some people develop plaque psoriasis and others don’t isn’t fully known, but a family history and environmental factors are thought to play a role.

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Common symptoms of plaque psoriasis include

  • Raised, red, silver, or flaky/scaly patches on your skin
  • Patches can be itchy and painful
  • Patches commonly appear on knees, elbows, lower back, and scalp
  • Patches on the genitalia, called genital psoriasis
  • Patches may also appear on other areas of the body

Illustration of 75% clearance and 100% clearance at 12 weeks. Individual results may vary.

“After starting Taltz, it started clearing up. The scales started going away. It wasn’t red and inflamed.”

Angie, actual Taltz patient with moderate to severe plaque psoriasis.

Angie was compensated for her time.

First of its kind*

Taltz is the first treatment of its kind* that offers a chance at
100% clear skin.

Take a look at our before-and-after images to see how Taltz works on moderate to severe plaque psoriasis.

See visible skin results

*Interleukin-17A (IL-17A) antagonist that includes 100% clear skin in the Prescribing Information.

How does Taltz work for patients with moderate to severe plaque psoriasis?

One protein in your body that plays a role in inflammation and skin plaque growth is interleukin-17A (IL-17A). Taltz is a biologic that targets IL-17A and helps to block it.*

*The relationship between how Taltz works and clinical outcomes has not been determined.

Your plaque psoriasis treatment options

There are many plaque psoriasis medications, so it’s important to talk with your doctor to find the one that’s right for you.

Some options for treatment include:

  • Topicals: Medicine used on the skin, such as a cream or lotion
  • Phototherapy: Medically supervised artificial light or sunlight therapy, which is used consistently on the affected skin
  • Systemics: Medicine taken by mouth in liquid or pill form, or given by injection, which works throughout the body
  • Biologics: Protein-based medicines produced from living cells that target specific parts of the immune system

You’re not in this alone

We’re by your side with guides that offer useful tips to inspire you on your path forward.

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Making it as easy as possible

The Taltz autoinjector can be used in the comfort of your home. Over 94% of adult patients agreed the Taltz autoinjector was "easy to use" and were confident in their ability to use it. Please see Instructions for Use included with the device.

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Adults may self-inject after receiving training from a healthcare provider.

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"Don’t go through that roller-coaster ride that I went through. Taltz worked extremely well for me, extremely well."

Cindy, actual Taltz patient with moderate to severe plaque psoriasis.

Cindy was compensated for her time.

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Warnings -

Taltz affects the immune system. It may increase your risk of infections, which can be serious. Do not use Taltz if you have any symptoms of infection, unless your doctor tells you to. If you have a symptom after starting Taltz, call your doctor right away.

Your doctor should check you for tuberculosis (TB) before you start Taltz, and watch you closely for signs of TB during and after treatment with Taltz. If you have TB, or had it in the past, your doctor may treat you for it before you start Taltz.

Do not use Taltz if you have had a serious allergic reaction to ixekizumab or any other ingredient in Taltz, such as: swelling of your eyelids, lips, mouth, tongue or throat, trouble breathing, feeling faint, throat or chest tightness, or skin rash. Get emergency help right away if you have any of these reactions. See the Medication Guide that comes with Taltz for a list of ingredients.

Crohn’s disease or ulcerative colitis (inflammatory bowel disease) can start or get worse with Taltz use. Tell your doctor if you have any of these symptoms or if they get worse: stomach pain, diarrhea, and weight loss.

You should not get live vaccines while taking Taltz. You should get the vaccines you need before you start Taltz.

Common side effects
The most common side effects of Taltz include:

  • Injection site reactions
  • Nausea
  • Upper respiratory infections
  • Fungal skin infections

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or

Before using

Before you use Taltz, review these questions with your doctor:

❑ Are you being treated for an infection?
❑ Do you have an infection that does not go away or keeps coming back?
❑ Do you have TB or have you been in close contact with someone with TB?
❑ Do you have possible symptoms of an infection such as fever, cough, sores, diarrhea, or other symptoms? Ask your doctor about other possible symptoms.
❑ Do you have Crohn’s disease or ulcerative colitis?

Tell your doctor if:

❑ You need any vaccines or have had one recently.
❑ You take prescription or over-the-counter medicines, vitamins, or herbal supplements.
❑ You are pregnant or planning to become pregnant. It is not known if Taltz can harm an unborn baby. Pregnancy Exposure Registry: There is a pregnancy registry to collect information about women who are exposed to Taltz during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. If you become pregnant while taking Taltz, you are encouraged to enroll in the pregnancy registry by calling 1-800-284-1695 or by visiting online at
❑ You are breastfeeding or planning to breastfeed. It is not known if Taltz passes into breastmilk.

How to take

See the instructions for use that come with Taltz. There you will find information about how to store, prepare, and inject Taltz. Adults may self-inject after receiving training from a healthcare provider.

For people under 18 years of age:

  • Weighing less than 50 kg (i.e., 110 lb): Taltz must be given by a healthcare provider.
  • Weighing more than 50 kg (i.e., 110 lb): If your healthcare provider decides that your caregiver may give your injections of Taltz at home, your caregiver should ask and receive training from a healthcare provider on the right way to prepare and inject Taltz.

Learn more

Taltz is a prescription medicine. For more information, call 1-800-545-5979 or go to

This summary provides basic information about Taltz but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Taltz and how to take it. Your doctor is the best person to help you decide if Taltz is right for you.


Taltz® and its delivery device base are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.


Taltz® (tȯl-ts) is an injectable medicine used to treat:

  • People 6 years of age and older with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
  • Adults with active psoriatic arthritis.
  • Adults with active ankylosing spondylitis.
  • Adults with active non-radiographic axial spondyloarthritis with objective signs of inflammation.

It is not known if Taltz is safe and effective in children for conditions other than plaque psoriasis or in children under 6 years of age.